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Physiologically‐based pharmacokinetic model of vaginally administered dapivirine ring and film formulations

AIMS: A physiologically‐based pharmacokinetic (PBPK) model of the vaginal space was developed with the aim of predicting concentrations in the vaginal and cervical space. These predictions can be used to optimize the probability of success of vaginally administered dapivirine (DPV) for HIV preventio...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Kay, Katherine, Shah, Dhaval K., Rohan, Lisa, Bies, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089833/
https://ncbi.nlm.nih.gov/pubmed/29714824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13625
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