Interleukin-1 in Monocyte Activation Phenotypes in Systemic Juvenile Idiopathic Arthritis: observations from a clinical trial of rilonacept, an interleukin-1 inhibitor

Systemic juvenile idiopathic arthritis (sJIA) is a childhood rheumatic disease of unknown origin. Dysregulated innate immunity is implicated in disease pathology. We investigated if IL-1 inhibition affects circulating cytokines and monocyte gene expression. CD14+ monocytes from patients in the RAPPO...

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Gepubliceerd in:Clin Immunol
Hoofdauteurs: Zhang, Yujuan, Gupta, Saloni, Ilstad-Minnihan, Alexandra, Ayyangar, Sashi, Hay, Arielle D., Pascual, Virginia, Ilowite, Norman T., Macaubas, Claudia, Mellins, Elizabeth D
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089654/
https://ncbi.nlm.nih.gov/pubmed/29928998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2018.06.005
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