The RAndomized Placebo Phase Study Of Rilonacept in the Treatment of Systemic Juvenile Idiopathic Arthritis (RAPPORT)

BACKGROUND: Interleukin-1 plays a pivotal role in in the pathogenesis of systemic juvenile idiopathic arthritis (sJIA). We assessed the efficacy and safety of rilonacept (IL-1 trap), an IL-1 inhibitor, in a randomized, double-blind, placebo-controlled trial. METHODS: An initial 4-week double-blind p...

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Vydáno v:Arthritis Rheumatol
Hlavní autoři: Ilowite, Norman T., Prather, Kristi, Lokhnygina, Yuliya, Schanberg, Laura E., Elder, Melissa, Milojevic, Diana, Verbsky, James W., Spalding, Steven J., Kimura, Yukiko, Imundo, Lisa F., Punaro, Marilynn G., Sherry, David D., Tarvin, Stacey E., Zemel, Lawrence S., Birmingham, James D., Gottlieb, Beth S., Miller, Michael L., O'Neil, Kathleen, Ruth, Natasha M., Wallace, Carol A., Singer, Nora G., Sandborg, Christy I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314719/
https://ncbi.nlm.nih.gov/pubmed/24839206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38699
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