Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass Spectrometry (HX-MS)

We have utilized hydrogen exchange-mass spectrometry (HX-MS) to characterize local backbone flexibility of four well-defined IgG1-Fc glycoforms expressed and purified from Pichia pastoris, two of which were prepared using subsequent in vitro enzymatic treatments. Progressively decreasing the size of...

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Udgivet i:J Pharm Sci
Main Authors: More, Apurva S., Toth, Ronald T., Okbazghi, Solomon Z., Middaugh, C. Russell, Joshi, Sangeeta B., Tolbert, Thomas J., Volkin, David B., Weis, David D.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089645/
https://ncbi.nlm.nih.gov/pubmed/29751008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.04.026
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