Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21

Medulloblastoma (MB) is the most common type of malignant childhood brain tumor. We previously showed that inhibitors of apoptosis proteins (IAP) small‐molecule inhibitors (LCL161 or LBW242) combined with chemotherapy have synergistic antiproliferative effects on MB cells. The synergistic antitumor...

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Bibliografische gegevens
Gepubliceerd in:Cancer Med
Hoofdauteurs: Chen, Shu‐Mei, Lin, Tzu‐Kang, Tseng, Yuan‐Yun, Tu, Chiao‐Hui, Lui, Tai‐Ngar, Huang, Shiang‐Fu, Hsieh, Ling‐Ling, Li, Ying‐Ying
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
Onderwerpen:
Cancer Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089189/
https://ncbi.nlm.nih.gov/pubmed/29984917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1658
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