Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21

Medulloblastoma (MB) is the most common type of malignant childhood brain tumor. We previously showed that inhibitors of apoptosis proteins (IAP) small‐molecule inhibitors (LCL161 or LBW242) combined with chemotherapy have synergistic antiproliferative effects on MB cells. The synergistic antitumor...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Chen, Shu‐Mei, Lin, Tzu‐Kang, Tseng, Yuan‐Yun, Tu, Chiao‐Hui, Lui, Tai‐Ngar, Huang, Shiang‐Fu, Hsieh, Ling‐Ling, Li, Ying‐Ying
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089189/
https://ncbi.nlm.nih.gov/pubmed/29984917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1658
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