Blockade of Inhibitors of Apoptosis Proteins in Combination with Conventional Chemotherapy Leads to Synergistic Antitumor Activity in Medulloblastoma and Cancer Stem-Like Cells

BACKGROUND: Medulloblastoma (MB) is the most common pediatric primary malignant brain tumor. Approximately one-third of MB patients succumb to treatment failure and some survivors suffer detrimental side effects. Hence, the purpose of this study is to explore new therapeutic regimens to overcome che...

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Veröffentlicht in:PLoS One
Hauptverfasser: Chen, Shu-Mei, Li, Ying-Ying, Tu, Chiao-Hui, Salazar, Nicole, Tseng, Yuan-Yun, Huang, Shiang-Fu, Hsieh, Ling-Ling, Lui, Tai-Ngar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990200/
https://ncbi.nlm.nih.gov/pubmed/27537345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161299
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