Blockade of inhibitors of apoptosis (IAPs) in combination with tumor-targeted delivery of tumor necrosis factor-α leads to synergistic antitumor activity

In the current study, we examined whether the combination of tumor vasculature-targeted gene therapy with adeno-associated virus bacteriophage-tumor necrosis factor-α (AAVP-TNF-α) and/or the orally administered LCL161, an antagonist of inhibitors of apoptosis proteins (IAPs), enhanced antitumor effi...

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Bibliographische Detailangaben
Hauptverfasser: Yuan, Z, Syrkin, G, Adem, A, Geha, R, Pastoriza, J, Vrikshajanani, C, Smith, T, Quinn, T J, Alemu, G, Cho, H, Barrett, C J, Arap, W, Pasqualini, R, Libutti, S K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534156/
https://ncbi.nlm.nih.gov/pubmed/23154431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2012.83
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