Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting

BACKGROUND: Genome editing by CRISPR-Cas9 technology allows large-scale screening of gene essentiality in cancer. A confounding factor when interpreting CRISPR-Cas9 screens is the high false-positive rate in detecting essential genes within copy number amplified regions of the genome. We have develo...

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Publicat a:BMC Genomics
Autors principals: Iorio, Francesco, Behan, Fiona M., Gonçalves, Emanuel, Bhosle, Shriram G., Chen, Elisabeth, Shepherd, Rebecca, Beaver, Charlotte, Ansari, Rizwan, Pooley, Rachel, Wilkinson, Piers, Harper, Sarah, Butler, Adam P., Stronach, Euan A., Saez-Rodriguez, Julio, Yusa, Kosuke, Garnett, Mathew J.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Methodology Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6088408/
https://ncbi.nlm.nih.gov/pubmed/30103702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-018-4989-y
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