Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects

BACKGROUND: CRISPR-Cas9 genome editing is widely used to study gene function, from basic biology to biomedical research. Structural rearrangements are a ubiquitous feature of cancer cells and their impact on the functional consequences of CRISPR-Cas9 gene-editing has not yet been assessed. RESULTS:...

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Detaylı Bibliyografya
Yayımlandı:Genome Biol
Asıl Yazarlar: Gonçalves, Emanuel, Behan, Fiona M., Louzada, Sandra, Arnol, Damien, Stronach, Euan A., Yang, Fengtang, Yusa, Kosuke, Stegle, Oliver, Iorio, Francesco, Garnett, Mathew J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2019
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362594/
https://ncbi.nlm.nih.gov/pubmed/30722791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1637-z
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