Combinatorial CRISPR screen identifies fitness effects of gene paralogues

Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours to survive despite having highly rearranged genomes. In this study we CRISPR screen 1191 gene pairs, including paralogues and known and...

Full description

Saved in:
Bibliographic Details
Published in:Nat Commun
Main Authors: Thompson, Nicola A., Ranzani, Marco, van der Weyden, Louise, Iyer, Vivek, Offord, Victoria, Droop, Alastair, Behan, Fiona, Gonçalves, Emanuel, Speak, Anneliese, Iorio, Francesco, Hewinson, James, Harle, Victoria, Robertson, Holly, Anderson, Elizabeth, Fu, Beiyuan, Yang, Fengtang, Zagnoli-Vieira, Guido, Chapman, Phil, Del Castillo Velasco-Herrera, Martin, Garnett, Mathew J., Jackson, Stephen P., Adams, David J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910459/
https://ncbi.nlm.nih.gov/pubmed/33637726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21478-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items