Combinatorial CRISPR screen identifies fitness effects of gene paralogues

Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours to survive despite having highly rearranged genomes. In this study we CRISPR screen 1191 gene pairs, including paralogues and known and...

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Publicat a:Nat Commun
Autors principals: Thompson, Nicola A., Ranzani, Marco, van der Weyden, Louise, Iyer, Vivek, Offord, Victoria, Droop, Alastair, Behan, Fiona, Gonçalves, Emanuel, Speak, Anneliese, Iorio, Francesco, Hewinson, James, Harle, Victoria, Robertson, Holly, Anderson, Elizabeth, Fu, Beiyuan, Yang, Fengtang, Zagnoli-Vieira, Guido, Chapman, Phil, Del Castillo Velasco-Herrera, Martin, Garnett, Mathew J., Jackson, Stephen P., Adams, David J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910459/
https://ncbi.nlm.nih.gov/pubmed/33637726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21478-9
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