Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening

Many gene fusions are reported in tumours and for most their role remains unknown. As fusions are used for diagnostic and prognostic purposes, and are targets for treatment, it is crucial to assess their function in cancer. To systematically investigate the role of fusions in tumour cell fitness, we...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Picco, Gabriele, Chen, Elisabeth D., Alonso, Luz Garcia, Behan, Fiona M., Gonçalves, Emanuel, Bignell, Graham, Matchan, Angela, Fu, Beiyuan, Banerjee, Ruby, Anderson, Elizabeth, Butler, Adam, Benes, Cyril H., McDermott, Ultan, Dow, David, Iorio, Francesco, Stronach, Euan, Yang, Fengtang, Yusa, Kosuke, Saez-Rodriguez, Julio, Garnett, Mathew J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522557/
https://ncbi.nlm.nih.gov/pubmed/31097696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09940-1
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