In Silico Identification of Piperidinyl-amine Derivatives as Novel Dual Binders of Oncogene c-myc/c-Kit G-quadruplexes

[Image: see text] In the last years, it has been shown that the DNA secondary structure known as G-quadruplex is also involved in the regulation of oncogenes transcription, such as c-myc, c-Kit, KRAS, Bcl-2, VEGF, and PDGF. DNA G-quadruplexes, formed in the promoter region of these proto-oncogenes,...

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I publikationen:ACS Med Chem Lett
Huvudupphovsmän: Rocca, Roberta, Moraca, Federica, Costa, Giosuè, Talarico, Carmine, Ortuso, Francesco, Da Ros, Silvia, Nicoletto, Giulia, Sissi, Claudia, Alcaro, Stefano, Artese, Anna
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2018
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6088347/
https://ncbi.nlm.nih.gov/pubmed/30128079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00275
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