Lineage tracing aged mouse kidneys shows lower number of cells of renin lineage and reduced responsiveness to RAAS inhibition

Blocking the renin-angiotensin-aldosterone system (RAAS) remains a mainstay of therapy in hypertension and glomerular diseases. With the population aging, our understanding of renin-producing cells in kidneys with advanced age is more critical than ever. Accordingly, we administered tamoxifen to Ren...

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Hamatani, Hiroko, Eng, Diana G., Kaverina, Natalya V., Gross, Kenneth W., Freedman, Benjamin S., Pippin, Jeffrey W., Shankland, Stuart J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087792/
https://ncbi.nlm.nih.gov/pubmed/29412700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00570.2017
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