Dual lineage tracing shows that glomerular parietal epithelial cells can transdifferentiate toward the adult podocyte fate

Podocytes are differentiated post-mitotic cells that cannot replace themselves after injury. Glomerular parietal epithelial cells are proposed to be podocyte progenitors. To test whether a subset of parietal epithelial cells transdifferentiate to a podocyte fate, dual reporter PEC-rtTA │LC1│tdTomato...

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Udgivet i:Kidney Int
Main Authors: Kaverina, Natalya V., Eng, Diana G., Freedman, Benjamin S., Kutz, J.Nathan, Chozinski, Tyler J., Vaughan, Joshua C., Miner, Jeffrey H., Pippin, Jeffrey W., Shankland, Stuart J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008116/
https://ncbi.nlm.nih.gov/pubmed/31200942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2019.03.014
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