Anti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT(3) Antagonist, Palonosetron and With the NK(1) Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in Suncus murinus (House Musk Shrew)

Ghrelin has well-known activity to stimulate appetite and weight gain. Evidence suggests that ghrelin may also have effects in reducing chemotherapy-induced emesis via growth hormone secretagogue receptors (GHS-R1A) in the brain. However, it is not known whether the stimulation of GHS-R1A has broad...

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Udgivet i:Front Pharmacol
Main Authors: Rudd, John A., Chan, Sze W., Ngan, Man P., Tu, Longlong, Lu, Zengbing, Giuliano, Claudio, Lovati, Emanuela, Pietra, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087754/
https://ncbi.nlm.nih.gov/pubmed/30127745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00869
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