Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome

IMPORTANCE: Colorectal carcinomas in patients with Lynch syndrome (LS) arise in a background of mismatch repair (MMR) deficiency, display a unique immune profile with upregulation of immune checkpoints, and response to immunotherapy. However, there is still a gap in understanding the pathogenesis of...

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Bibliografski detalji
Izdano u:JAMA Oncol
Glavni autori: Chang, Kyle, Taggart, Melissa W., Reyes-Uribe, Laura, Borras, Ester, Riquelme, Erick, Barnett, Reagan M., Leoni, Guido, San Lucas, F. Anthony, Catanese, Maria T., Mori, Federica, Diodoro, Maria G., You, Y. Nancy, Hawk, Ernest T., Roszik, Jason, Scheet, Paul, Kopetz, Scott, Nicosia, Alfredo, Scarselli, Elisa, Lynch, Patrick M., McAllister, Florencia, Vilar, Eduardo
Format: Artigo
Jezik:Inglês
Izdano: American Medical Association 2018
Teme:
Original Investigation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087485/
https://ncbi.nlm.nih.gov/pubmed/29710228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2018.1482
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