In Silico Systems Biology Analysis of Variants of Uncertain Significance in Lynch Syndrome Supports the Prioritization of Functional Molecular Validation

Lynch syndrome (LS) is a genetic condition secondary to germline alterations in the DNA mismatch repair (MMR) genes with 30% of changes being variants of uncertain significance (VUS). Our aim was to perform an in silico re-classification of VUS from a large single institutional cohort that will help...

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Detalhes bibliográficos
Publicado no:Cancer Prev Res (Phila)
Main Authors: Borras, Ester, Chang, Kyle, Pande, Mala, Cuddy, Amanda, Bosch, Jennifer L, Bannon, Sarah A, Mork, Maureen E, Rodriguez-Bigas, Miguel A, Taggart, Melissa W, Lynch, Patrick M, You, Y. Nancy, Vilar, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626617/
https://ncbi.nlm.nih.gov/pubmed/28765196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-17-0058
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