Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome

IMPORTANCE: Colorectal carcinomas in patients with Lynch syndrome (LS) arise in a background of mismatch repair (MMR) deficiency, display a unique immune profile with upregulation of immune checkpoints, and response to immunotherapy. However, there is still a gap in understanding the pathogenesis of...

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Publicado en:JAMA Oncol
Autores principales: Chang, Kyle, Taggart, Melissa W., Reyes-Uribe, Laura, Borras, Ester, Riquelme, Erick, Barnett, Reagan M., Leoni, Guido, San Lucas, F. Anthony, Catanese, Maria T., Mori, Federica, Diodoro, Maria G., You, Y. Nancy, Hawk, Ernest T., Roszik, Jason, Scheet, Paul, Kopetz, Scott, Nicosia, Alfredo, Scarselli, Elisa, Lynch, Patrick M., McAllister, Florencia, Vilar, Eduardo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Medical Association 2018
Materias:
Original Investigation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087485/
https://ncbi.nlm.nih.gov/pubmed/29710228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2018.1482
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