Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome

IMPORTANCE: Colorectal carcinomas in patients with Lynch syndrome (LS) arise in a background of mismatch repair (MMR) deficiency, display a unique immune profile with upregulation of immune checkpoints, and response to immunotherapy. However, there is still a gap in understanding the pathogenesis of...

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Detalhes bibliográficos
Publicado no:JAMA Oncol
Main Authors: Chang, Kyle, Taggart, Melissa W., Reyes-Uribe, Laura, Borras, Ester, Riquelme, Erick, Barnett, Reagan M., Leoni, Guido, San Lucas, F. Anthony, Catanese, Maria T., Mori, Federica, Diodoro, Maria G., You, Y. Nancy, Hawk, Ernest T., Roszik, Jason, Scheet, Paul, Kopetz, Scott, Nicosia, Alfredo, Scarselli, Elisa, Lynch, Patrick M., McAllister, Florencia, Vilar, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2018
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087485/
https://ncbi.nlm.nih.gov/pubmed/29710228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2018.1482
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