Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome

IMPORTANCE: Colorectal carcinomas in patients with Lynch syndrome (LS) arise in a background of mismatch repair (MMR) deficiency, display a unique immune profile with upregulation of immune checkpoints, and response to immunotherapy. However, there is still a gap in understanding the pathogenesis of...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:JAMA Oncol
Κύριοι συγγραφείς: Chang, Kyle, Taggart, Melissa W., Reyes-Uribe, Laura, Borras, Ester, Riquelme, Erick, Barnett, Reagan M., Leoni, Guido, San Lucas, F. Anthony, Catanese, Maria T., Mori, Federica, Diodoro, Maria G., You, Y. Nancy, Hawk, Ernest T., Roszik, Jason, Scheet, Paul, Kopetz, Scott, Nicosia, Alfredo, Scarselli, Elisa, Lynch, Patrick M., McAllister, Florencia, Vilar, Eduardo
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Medical Association 2018
Θέματα:
Original Investigation
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6087485/
https://ncbi.nlm.nih.gov/pubmed/29710228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2018.1482
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