Structure of the human volume regulated anion channel

SWELL1 (LRRC8A) is the only essential subunit of the Volume Regulated Anion Channel (VRAC), which regulates cellular volume homeostasis and is activated by hypotonic solutions. SWELL1, together with four other LRRC8 family members, potentially forms a vastly heterogeneous cohort of VRAC channels wit...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kefauver, Jennifer M, Saotome, Kei, Dubin, Adrienne E, Pallesen, Jesper, Cottrell, Christopher A, Cahalan, Stuart M, Qiu, Zhaozhu, Hong, Gunhee, Crowley, Christopher S, Whitwam, Tess, Lee, Wen-Hsin, Ward, Andrew B, Patapoutian, Ardem
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086657/
https://ncbi.nlm.nih.gov/pubmed/30095067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38461
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