LRRC8 proteins form volume-regulated anion channels that sense ionic strength

The volume-regulated anion channel (VRAC) is activated when a cell swells, and plays a central role in maintaining cell volume in response to osmotic challenges. SWELL1 (LRRC8A) was recently identified as an essential component of VRAC. However, the identity of the pore-forming subunits of VRAC, and...

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Bibliografische gegevens
Gepubliceerd in:Cell
Hoofdauteurs: Syeda, Ruhma, Qiu, Zhaozhu, Dubin, Adrienne E., Murthy, Swetha E., Florendo, Maria N., Mason, Daniel E., Mathur, Jayanti, Cahalan, Stuart M., Peters, Eric C., Montal, Mauricio, Patapoutian, Ardem
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733249/
https://ncbi.nlm.nih.gov/pubmed/26824658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.12.031
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