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AMPK promotes tolerance to Ras pathway inhibition by activating autophagy
Targeted inhibitors of oncogenic Ras (rat sarcoma viral oncogene)-Raf signaling have shown great promise in the clinic, but resistance remains a major challenge: 30% of tumors with pathway mutations do not respond to targeted inhibitors, and of the 70% that do respond, all eventually develop resista...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6086350/ https://ncbi.nlm.nih.gov/pubmed/27041569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.70 |
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