Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy

We previously demonstrated that proto-oncogene Fyn decreased energy expenditure and increased metabolic phenotypes. Also Fyn decreased autophagy-mediated muscle mass by directly inhibiting LKB1 and stimulating STAT3 activities, respectively. AMPK, a downstream target of LKB1, was recently identified...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Yamada, Eijiro, Okada, Shuichi, Bastie, Claire C., Vatish, Manu, Nakajima, Yasuyo, Shibusawa, Ryo, Ozawa, Atsushi, Pessin, Jeffrey E., Yamada, Masanobu
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper: Autophagy and Cell Death
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340180/
https://ncbi.nlm.nih.gov/pubmed/27626315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11916
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