Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

Adenosine monophosphate-activated protein kinase (AMPK) acts as a major sensor of cellular energy status in cancers and is critically involved in cell sensitivity to anticancer agents. Here, we showed that AMPK was inactivated in lymphoma and related to the upregulation of the mammalian target of ra...

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Detalhes bibliográficos
Main Authors: Shi, W-Y, Xiao, D, Wang, L, Dong, L-H, Yan, Z-X, Shen, Z-X, Chen, S-J, Chen, Y, Zhao, W-L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317343/
https://ncbi.nlm.nih.gov/pubmed/22378068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.13
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