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Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis

BACKGROUND: Metformin has been shown to inhibit the proliferation and migration of vascular wall cells. However, the mechanism through which metformin acts on atherosclerosis (AS) via the long non-coding RNA taurine up-regulated gene 1 (lncRNA TUG1) is still unknown. Thus, this research investigated...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: You, Ganhua, Long, Xiangshu, Song, Fang, Huang, Jing, Tian, Maobo, Xiao, Yan, Deng, Shiyan, Wu, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006854/
https://ncbi.nlm.nih.gov/pubmed/32099330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S233932
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