Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway

Random-pattern skin flaps are widely used to close defects in reconstructive and plastic surgeries; however, they are vulnerable to necrosis, particularly in the distal portion of the flap. Here, we examined the effects of metformin on flap survival and the mechanisms underlying these effects. Follo...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Biol Sci
Hauptverfasser: Wu, Hongqiang, Ding, Jian, Li, Shihen, Lin, Jinti, Jiang, Renhao, Lin, Chen, Dai, Li, Xie, Chenglong, Lin, Dingsheng, Xu, Huazi, Gao, Weiyang, Zhou, Kailiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367544/
https://ncbi.nlm.nih.gov/pubmed/30745824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.29009
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