Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition

Vitamin K epoxide reductase (VKOR), an endoplasmic reticulum membrane protein, is the key enzyme for vitamin K–dependent carboxylation, a posttranslational modification that is essential for the biological functions of coagulation factors. VKOR is the target of the most widely prescribed oral antico...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Wu, Sangwook, Chen, Xuejie, Jin, Da-Yun, Stafford, Darrel W., Pedersen, Lee G., Tie, Jian-Ke
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085993/
https://ncbi.nlm.nih.gov/pubmed/29743176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-01-830901
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