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Human Vitamin K Epoxide Reductase and Its Bacterial Homologue Have Different Membrane Topologies and Reaction Mechanisms

Vitamin K epoxide reductase (VKOR) is essential for the production of reduced vitamin K that is required for modification of vitamin K-dependent proteins. Three- and four-transmembrane domain (TMD) topology models have been proposed for VKOR. They are based on in vitro glycosylation mapping of the h...

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Detalhes bibliográficos
Main Authors: Tie, Jian-Ke, Jin, Da-Yun, Stafford, Darrel W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464505/
https://ncbi.nlm.nih.gov/pubmed/22923610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402941
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