The transcriptional co-activator TAZ is a potent mediator of alveolar rhabdomyosarcoma tumorigenesis

PURPOSE: Alveolar rhabdomyosarcoma (aRMS) is a childhood soft tissue sarcoma driven by the signature PAX3-FOXO1 (P3F) fusion gene. 5-year survival for aRMS is <50%, with no improvement in over four decades. Although the transcriptional co-activator TAZ is oncogenic in carcinomas, the role of TAZ...

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Udgivet i:Clin Cancer Res
Main Authors: Deel, Michael D., Slemmons, Katherine K., Hinson, Ashley R., Genadry, Katia C., Burgess, Breanne A., Crose, Lisa E.S., Kuprasertkul, Nina, Oristian, Kristianne M., Bentley, Rex C., Linardic, Corinne M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085878/
https://ncbi.nlm.nih.gov/pubmed/29514840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1207
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