Alveolar rhabdomyosarcoma–associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression

Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the paired box 3-forkhead box protein O1 (PAX3-FOXO1) fusion oncogene. Despite its discovery nearly two decades ago, the mechanisms by which PAX3-FOXO1 drives tumor development are not well ch...

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Autores principales: Crose, Lisa E.S., Galindo, Kathleen A., Kephart, Julie Grondin, Chen, Candy, Fitamant, Julien, Bardeesy, Nabeel, Bentley, Rex C., Galindo, Rene L., Ashley Chi, Jen-Tsan, Linardic, Corinne M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871220/
https://ncbi.nlm.nih.gov/pubmed/24334454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67087
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