Isobenzofuranone derivative JVPH3, an inhibitor of L. donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites

Kinetoplast DNA (kDNA) bearing unusual mitochondrion of trypanosomatid parasites offers a new paradigm in chemotherapy modality. Topoisomerase II of Leishmania donovani (LdTopII), a key enzyme associated with kDNA replication, is emerging as a potential drug target. However, mode of action of LdTopI...

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Pubblicato in:Sci Rep
Autori principali: Chowdhury, Somenath Roy, Godinho, Joseane Lima Prado, Vinayagam, Jayaraman, Zuma, Aline Araujo, Silva, Sara Teixeira De Macedo, Jaisankar, Parasuraman, Rodrigues, Juliany Cola Fernandes, De Souza, Wanderley, Majumder, Hemanta K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085290/
https://ncbi.nlm.nih.gov/pubmed/30093616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30405-w
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