Bi-allelic loss of CDKN2A initiates melanoma invasion via BRN2 activation

Loss of the CDKN2A tumor suppressor is associated with melanoma metastasis, but the mechanisms connecting the phenomena are unknown. Using CRISPR-Cas9 to engineer a cellular model of melanoma initiation from primary human melanocytes, we discovered that a lineage restricted transcription factor, BRN...

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Publicat a:Cancer Cell
Autors principals: Zeng, Hanlin, Jorapur, Aparna, Shain, A. Hunter, Lang, Ursula E., Torres, Rodrigo, Zhang, Yuntian, McNeal, Andrew S., Botton, Thomas, Lin, Jue, Donne, Matthew, Bastian, Ingmar N., Yu, Richard, North, Jeffrey P., Pincus, Laura, Ruben, Beth S., Joseph, Nancy M, Yeh, Iwei, Bastian, Boris C., Judson, Robert L.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6084788/
https://ncbi.nlm.nih.gov/pubmed/29990501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.014
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