Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution

We elucidated genomic and transcriptomic changes that accompany the evolution of melanoma from premalignant lesions by sequencing DNA and RNA from primary melanomas and their adjacent precursors, as well as matched primary tumors and regional metastases. In total, we analyzed 230 histopathologically...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Shain, A. Hunter, Joseph, Nancy M., Yu, Richard, Benhamida, Jamal, Liu, Shanshan, Prow, Tarl, Ruben, Beth, North, Jeffrey, Pincus, Laura, Yeh, Iwei, Judson, Robert, Bastian, Boris C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319271/
https://ncbi.nlm.nih.gov/pubmed/29990500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.06.005
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