Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution

We elucidated genomic and transcriptomic changes that accompany the evolution of melanoma from premalignant lesions by sequencing DNA and RNA from primary melanomas and their adjacent precursors, as well as matched primary tumors and regional metastases. In total, we analyzed 230 histopathologically...

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Publicat a:Cancer Cell
Autors principals: Shain, A. Hunter, Joseph, Nancy M., Yu, Richard, Benhamida, Jamal, Liu, Shanshan, Prow, Tarl, Ruben, Beth, North, Jeffrey, Pincus, Laura, Yeh, Iwei, Judson, Robert, Bastian, Boris C.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319271/
https://ncbi.nlm.nih.gov/pubmed/29990500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.06.005
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