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Bi-allelic loss of CDKN2A initiates melanoma invasion via BRN2 activation
Loss of the CDKN2A tumor suppressor is associated with melanoma metastasis, but the mechanisms connecting the phenomena are unknown. Using CRISPR-Cas9 to engineer a cellular model of melanoma initiation from primary human melanocytes, we discovered that a lineage restricted transcription factor, BRN...
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| Published in: | Cancer Cell |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6084788/ https://ncbi.nlm.nih.gov/pubmed/29990501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.05.014 |
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