L3MBTL2 orchestrates ubiquitin signaling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage

Cells respond to cytotoxic DNA double strand breaks by recruiting DNA repair proteins to the damaged site. This recruitment is dependent on ubiquitylation of adjacent chromatin areas by E3 ubiquitin ligases such as RNF8 and RNF168. RNF8 and RNF168 are recruited sequentially to the double strand brea...

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Pubblicato in:Nat Cell Biol
Autori principali: Nowsheen, Somaira, Aziz, Khaled, Aziz, Asef, Deng, Min, Qin, Bo, Luo, Kuntian, Jeganathan, Karthikbabu B, Zhang, Henan, Liu, Tongzheng, Yu, Jia, Deng, Yibin, Yuan, Jian, Ding, Wei, van Deursen, Jan M, Lou, Zhenkun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083879/
https://ncbi.nlm.nih.gov/pubmed/29581593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0071-x
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