ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Cells respond to cytotoxic DNA double-strand breaks by recruiting repair proteins to the damaged site. Phosphorylation of the histone variant H2AX at S139 and Y142 modulate its interaction with downstream DNA repair proteins and their recruitment to DNA lesions. Here we report ATM-dependent ZNF506 l...

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Publicat a:Nat Commun
Autors principals: Nowsheen, Somaira, Aziz, Khaled, Luo, Kuntian, Deng, Min, Qin, Bo, Yuan, Jian, Jeganathan, Karthik B., Yu, Jia, Zhang, Henan, Ding, Wei, van Deursen, Jan M., Lou, Zhenkun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048040/
https://ncbi.nlm.nih.gov/pubmed/30013081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05161-0
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