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Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease
A series of indole derivatives was designed and synthesised to improve on activity and circumvent pharmacokinetic limitations experienced with the structurally related compound, ladostigil. The compounds consisted of a propargylamine moiety (a known MAO inhibitor and neuroprotector) at the N1 positi...
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| Pubblicato in: | Medchemcomm |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6083799/ https://ncbi.nlm.nih.gov/pubmed/30108930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00569e |
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