Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents

Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer’s disease (AD). Coumarin derivatives serve as a good starting point for designing MTDLs due to their inherent inhibition of monoamine oxidase (MAO) and cholinesterase enzymes, which are complicit in AD’s c...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Mzezewa, Sheunopa C., Omoruyi, Sylvester I., Zondagh, Luke S., Malan, Sarel F., Ekpo, Okobi E., Joubert, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291583/
https://ncbi.nlm.nih.gov/pubmed/34281458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1913137
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