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Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents

A series of multi-target directed edaravone derivatives bearing N-benzyl pyridinium moieties were designed and synthesised. Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited positive results as part of a dual-site binding, per...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Zondagh, Luke S., Malan, Sarel F., Joubert, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470113/
https://ncbi.nlm.nih.gov/pubmed/32779503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1801673
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