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A novel allosteric inhibitor that prevents IKKβ activation
I kappa B kinase β (IKKβ) is one of the primary targets to regulate canonical NF-κB activity. The misregulation of NF-κB is associated with various diseases, including chronic inflammation and cancers. Most of the known IKKβ inhibitors target its active form and suffer from poor selectivity. In the...
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| Pubblicato in: | Medchemcomm |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6083782/ https://ncbi.nlm.nih.gov/pubmed/30108917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00599g |
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