Regional Distribution of CNS Antigens Differentially Determines T-Cell Mediated Neuroinflammation in a CX3CR1-Dependent Manner

T cells continuously sample CNS-derived antigens in the periphery, yet it is unknown how they sample and respond to CNS antigens derived from distinct brain areas. We expressed ovalbumin (OVA) neoepitopes in regionally distinct CNS areas (Cnp-OVA and Nes-OVA mice) to test peripheral antigen sampling...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Rayasam, Aditya, Kijak, Julie A., Dallmann, McKenna, Hsu, Martin, Zindl, Nicole, Lindstedt, Anders, Steinmetz, Leah, Harding, Jeffrey S., Harris, Melissa G., Karman, Jozsef, Sandor, Matyas, Fabry, Zsuzsanna
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083460/
https://ncbi.nlm.nih.gov/pubmed/29959236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0366-18.2018
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