Regional Distribution of CNS Antigens Differentially Determines T-Cell Mediated Neuroinflammation in a CX3CR1-Dependent Manner

T cells continuously sample CNS-derived antigens in the periphery, yet it is unknown how they sample and respond to CNS antigens derived from distinct brain areas. We expressed ovalbumin (OVA) neoepitopes in regionally distinct CNS areas (Cnp-OVA and Nes-OVA mice) to test peripheral antigen sampling...

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Dades bibliogràfiques
Publicat a:J Neurosci
Autors principals: Rayasam, Aditya, Kijak, Julie A., Dallmann, McKenna, Hsu, Martin, Zindl, Nicole, Lindstedt, Anders, Steinmetz, Leah, Harding, Jeffrey S., Harris, Melissa G., Karman, Jozsef, Sandor, Matyas, Fabry, Zsuzsanna
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083460/
https://ncbi.nlm.nih.gov/pubmed/29959236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0366-18.2018
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