Regional Distribution of CNS Antigens Differentially Determines T-Cell Mediated Neuroinflammation in a CX3CR1-Dependent Manner

T cells continuously sample CNS-derived antigens in the periphery, yet it is unknown how they sample and respond to CNS antigens derived from distinct brain areas. We expressed ovalbumin (OVA) neoepitopes in regionally distinct CNS areas (Cnp-OVA and Nes-OVA mice) to test peripheral antigen sampling...

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Vydáno v:J Neurosci
Hlavní autoři: Rayasam, Aditya, Kijak, Julie A., Dallmann, McKenna, Hsu, Martin, Zindl, Nicole, Lindstedt, Anders, Steinmetz, Leah, Harding, Jeffrey S., Harris, Melissa G., Karman, Jozsef, Sandor, Matyas, Fabry, Zsuzsanna
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2018
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083460/
https://ncbi.nlm.nih.gov/pubmed/29959236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0366-18.2018
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