Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) integrates viral DNA into the host genome using its 3′-end processing and strand-transfer activities. Due to the importance of HIV-1 IN, it is targeted by the newest class of approved drugs known as integrase strand transfer inhibitors (INST...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Rogers, Leonard, Obasa, Adetayo E., Jacobs, Graeme B., Sarafianos, Stefan G., Sönnerborg, Anders, Neogi, Ujjwal, Singh, Kamalendra
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083056/
https://ncbi.nlm.nih.gov/pubmed/30116231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.01754
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