Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa

HIV-Integrase (IN) has proven to be a viable target for highly specific HIV-1 therapy. We aimed to characterize the HIV-1 IN gene in a South African context and identify resistance-associated mutations (RAMs) against available first and second generation Integrase strand-transfer inhibitors (InSTIs)...

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Vydáno v:Sci Rep
Hlavní autoři: Brado, Dominik, Obasa, Adetayo Emmanuel, Ikomey, George Mondinde, Cloete, Ruben, Singh, Kamalendra, Engelbrecht, Susan, Neogi, Ujjwal, Jacobs, Graeme Brendon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856838/
https://ncbi.nlm.nih.gov/pubmed/29549274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22914-5
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