Strain-specific Effect on Biphasic DNA Binding by HIV-1 Integrase

The oligomerization of HIV-1 integrase onto DNA is not well understood. Here we show that HIV-1 integrase binds the DNA in a biphasic (high- and low-affinity) modes. For HIV-1 subtype B, the high-affinity mode is ~100-fold greater than low-affinity mode (K(d.DNA)=37 and 3400 nM, respectively). The K...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:AIDS
Prif Awduron: Hill, Kyle J., Rogers, Leonard C., Njenda, Duncan T., Burke, Donald H., Sarafianos, Stefan G., Sönnerborg, Anders, Neogi, Ujjwal, Singh, Kamalendra
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472922/
https://ncbi.nlm.nih.gov/pubmed/30475264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000002078
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