Llwytho...
Strain-specific Effect on Biphasic DNA Binding by HIV-1 Integrase
The oligomerization of HIV-1 integrase onto DNA is not well understood. Here we show that HIV-1 integrase binds the DNA in a biphasic (high- and low-affinity) modes. For HIV-1 subtype B, the high-affinity mode is ~100-fold greater than low-affinity mode (K(d.DNA)=37 and 3400 nM, respectively). The K...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | AIDS |
|---|---|
| Prif Awduron: | , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6472922/ https://ncbi.nlm.nih.gov/pubmed/30475264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000002078 |
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