Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) where pathology is thought to be regulated by autoreactive T cells of the Th1 and Th17 phenotype. In this study we sought to understand the functions of Presenilin 1 (PSEN1) in regulating T cell effe...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cummings, Matthew, Arumanayagam, Anitha Christy Sigamani, Zhao, Picheng, Kannanganat, Sunil, Stuve, Olaf, Karandikar, Nitin J., Eagar, Todd N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082653/
https://ncbi.nlm.nih.gov/pubmed/30089166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200752
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