Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus

Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several “enabling pairs” of neutralizing and non-neutralizing anti-ebolavirus monoclonal antibo...

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Pubblicato in:Cell Rep
Autori principali: Howell, Katie A., Brannan, Jennifer M., Bryan, Christopher, McNeal, Andrew, Davidson, Edgar, Turner, Hannah L., Vu, Hong, Shulenin, Sergey, He, Shihua, Kuehne, Ana, Herbert, Andrew S., Qiu, Xiangguo, Doranz, Benjamin J., Holtsberg, Frederick W., Ward, Andrew B., Dye, John M., Aman, M. Javad
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Author(s). 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082427/
https://ncbi.nlm.nih.gov/pubmed/28402862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.049
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